Thrombolytic Therapy

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اشترك في: الخميس إبريل 04, 2013 10:28 pm

Thrombolytic Therapy

مشاركةبواسطة دكتور كمال سيد » الأحد نوفمبر 18, 2018 6:26 pm

The most commonly used drug for thrombolytic therapy is Tissue Plasminogen Activator (tPA), but other drugs can do the same thing. ... Thrombolytics work by dissolving a major clot quickly. This helps restart blood flow to the heart and helps prevent damage to the heart muscle.

Examples of thrombolytic medications include:

alteplase (Activase)
streptokinase (Streptase)
tissue plasminogen activator.
urokinase (Kinlytic)

for ischemic strokes
The only FDA approved treatment for ischemic strokes is tissue plasminogen activator (tPA, also known as IV rtPA, given through an IV in the arm). tPA works by dissolving the clot and improving blood flow to the part of the brain being deprived of blood flow.

What is tPA and how does it work?
Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC found on endothelial cells, the cells that line the blood vessels.

Can tPA be given more than once?
Unlike drugs such as Vioxx, which were prescribed for daily use to masses of patients only to show unanticipated adverse effects, tPA for stroke is usually given once, intravenously. ... Most have been by now been convinced, but tPA has been the most controversial drug ever used in neurology. ... ombolytics


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